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If there was one thing that I could change in this essay, it would be to clearly outline that the existence of nanotechnology advanced enough to do things like melt GPUs isn't necessary even if it is sufficient for achieving singleton status and taking humanity off the field as a meaningful player.

Whenever I see people fixate on critiquing that particular point, I need to step in and point out that merely existing tools and weapons (is there a distinction?) suffice for a Superintelligence to be able to kill the vast majority of humans and reduce our threat to it to negligible levels. Be that wresting control of nuclear arsenals to initiate MAD or simply extrapolating on gain-of-function research to produce extremely virulent yet lethal pathogens that can't be defeated before the majority of humans are infected, such options leave a small minority of humans alive to cower in the wreckage until the biosphere is later dismantled.

That's orthogonal to the issue of whether such nanotechnology is achievable for a Superintelligent AGI, it merely reduces the inferential distance the message has to be conveyed as it doesn't demand familiarity with Drexler.

(Advanced biotechnology already is nanotechnology, but the point is that no stunning capabilities need to be unlocked for an unboxed AI to become immediately lethal)